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associated with the largest weight loss outcomes, with some participants losing over 24% of their body weight across 48 weeks Kaur, Manmeet, and Saurav Misra

While formal exercise programs are not required for weight loss with these medications, physical activity may provide additional benefits for weight maintenance and overall health

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Clinical trials showed Retatrutide producing an average 24.2% body weight reduction over 48 weeks at the highest dose tested, making it the most effective weight loss compound ever studied in clinical trials