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Taken together, the clinical and preclinical studies summarized in Table X indicate that microbiota-targeted interventions generally produce modest but clinically measurable improvements rather than disease remission

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6 Low vitamin D has been linked to higher disease activity in some studies

Food and Drug Administration (FDA), European Medicines Agency (EMA), Pharmaceuticals and Medical Devices Agency (PMDA, Japan), Therapeutic Goods Administration (TGA, Australia), Health Canada, and Medsafe (New Zealand)

It is not a substitute for specific medications aimed at managing lipids when those are necessary

Investigating how diet and the microbiome modulate MMP activity could pave the way for lifestyle-based adjunctive therapies, with emerging evidence suggesting that Mediterranean diet adherence and weight management may significantly improve clinical outcomes