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47 In patients with overweight or obesity without diabetes, the Tirzepatide Once Weekly for the Treatment of Obesity (SURMOUNT-1) trial showed that tirzepatide 15 mg weekly led to a mean body weight reduction of 20.9% after 72 weeks of treatment, compared with 3.1% with placebo

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Irisin enhances the polarization of anti-inflammatory variants of macrophages to the M2 subtype in adipose tissue

Similarly, no group separation was found in the liver, with only 20 proteins induced by GLP-1GIPLani and 17 induced by GLP-1GIP (out of which 16 overlapped), and no clear pathway enrichment (Extended Data Fig

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