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Description
1996;2:S209S215
E.JungJ
1997 beta-Amino Acids: Versatile Peptidomimetics Steer DL, Lew RA, Perlmutter P, Smith AI and Aguilar M-I Curr
The Phase 2 trial tested four dose levels, and the dose-response curve was remarkably linear
MitoTEMPO MitoTEMPO is a mitochondria-targeted SOD mimetic that consists of piperidine nitroxide (2,2,6,6-tetramethylpiperidine- 1 -oxy) conjugated to the lipophilic triphenylphosphonium cation (TPP + ) that facilitates the membrane potential-dependent accumulation of the compound into the matrix 92
It was noted that protection mediated by passive transfer of immune sera was lost in mice lacking expression of activating FcRs, in particular FcRIII, or depleted of alveolar macrophages
