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Tirzepatides, such as Mounjaro and Zepbound, are technically classified differently because they incorporate agonists of both GLP-1 and another hormone called glucose-dependent insulinotropic polypeptide (GIP)

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It has been shown that GLP-1R is also expressed in BMSCs, and liraglutide promotes osteogenic differentiation, inhibits lipogenic differentiation and reduces cell death, protects against bone loss and fracture, and promotes bone formation in rat and human BMSCs (Jeon et al., 2014

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Retatrutide appears to push the boundaries further with its third receptor target

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Newer GLP-1RAs have lots of benefits

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Decision matrix Safety considerations researchers should know Both compounds are newer than established GLP-1 agonists , which means their long-term safety profiles are still being characterized

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[DOI] [PubMed] [Google Scholar] 10.Vallon V

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