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The purpose is to help your body adjust comfortably, especially if you are sensitive to GLP-1 medications or prone to nausea and digestive side effects

Muscle-related concerns on tirzepatide are valid but often overstated

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In SURMOUNT-2 (adults with obesity/overweight and type 2 diabetes), tirzepatide achieved up to about 15.7% at 72 weeks

[1] [30] Other common effects include occasional vomiting, diarrhea, constipation, and abdominal discomfort

NeuroImage 51(3):12421252 [DOI] [PMC free article] [PubMed] [Google Scholar] Zhang L, Zhang W, Tian X (2023) The pleiotropic of GLP-1/GLP-1R axis in central nervous system diseases