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[5] Additionally, some patients may experience changes in lipid profiles, liver enzymes, or kidney function markers as their metabolic health improves or if side effects such as dehydration from gastrointestinal symptoms develop

Of note, there was also an increased rate of amputation noted for unknown mechanisms [23]

For context, existing FDA-approved medications for alcohol use disorder, like naltrexone and acamprosate, typically show reductions in the range of 15 to 25%

The STEP clinical trials demonstrated that semaglutide produced average weight loss of 15% over 68 weeks, while tirzepatide achieved 2022% in similar studies

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One caveat, though: The medications need to be refrigerated, and if your refrigerator is too cold, the medication will freeze and the whole mechanism will get jammed up