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In this issue of Diabetologia, Kang et al (DOI: 10.1007/s00125-012-2776-x ) provide evidence that in addition to glucotoxicity, lipotoxicity also affects incretin receptor expression and signalling in insulin-secreting cells and isolated islets

Edelman answers a common question about how they can be included in a diabetes management regimen with regard to metformin.

Hangzhou Sciwind Biosciences claims its drug ecnoglutide delivers over 15% weight loss at highest dose after 48 weeks.

Appetite & weight-related signaling

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