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Peptides that influenced multiple physiological pathways were often deemed too complex for therapeutic development, particularly when early studies revealed off-target effects at supraphysiologic doses

doi: 10.1097/01.NAJ.0001016352.54091.a1

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Evidence for longer-term effects beyond two years was more limited

doi:10.1152/ajpendo.00337.2014 67

320 These observations were confirmed in ob/ob mice and high-fat-fed mice when they were treated with a GIPR antagonist, and also in mice lacking GIP-secreting K cells, confirming the important role of GIP in fat accumulation