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Most cases are mild and improve over time without stopping treatment

Almost everyone is overweight: 71% of Americans are either overweight or obese

Be sure to inject Mounjaro and insulin separately

The STEP (Semaglutide Treatment Effect in People with obesity) trials demonstrated that weight loss achieved with semaglutide can lead to reductions in alanine aminotransferase (ALT) and aspartate aminotransferase (AST)liver enzymes that, when elevated, indicate hepatic inflammation or damage

Obesity also induces macrophage polarization, shifting from an M2 (anti-inflammatory) to an M1 (pro-inflammatory) phenotype, leading to the formation of crown-like structures (CLS) around necrotic adipocytes [18]

Indeed, early preclinical studies demonstrated attenuation of renal TGF- expression in association with reduced expression of collagens within the kidney after GLP-1 receptor agonist therapy (62)