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The pattern is uncomfortable but clear: the single largest, best-powered Alzheimers trial of this class was negative, while the positive evidence is observational or confined to secondary endpoints in underpowered studies

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Liraglutide also carries warnings about pancreatitis, liraglutide pen sharing, hypoglycemia when used in conjunction with certain other drugs known to cause hypoglycemia including insulin and sulfonylurea, renal impairment or kidney failure, hypersensitivity and acute gallbladder disease

Financially, the deal is not expected to affect Novo Nordisks previously guided 2025 operating profit outlook

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