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But the longer answer involves understanding what actually causes plateaus and whether timing plays any role

The most commonly reported and clinically significant overlapping effects involve the gastrointestinal system, metabolic disturbances, and central nervous system symptoms

Metformin, in particular, is often maintained as foundational therapy due to its low cost, weight neutrality, and long-term clinical experience
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Theyre FDA approved for different uses

Changes in digestion or gastrointestinal issues
