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Neither semaglutide nor tirzepatide activates glucagon receptors, which is precisely why their heart rate effects are smaller

[DOI] [PMC free article] [PubMed] [Google Scholar] 26.Yaqub T, et al

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The landmark FLOW trial , published in the New England Journal of Medicine in 2024, demonstrated that semaglutide reduced the risk of major kidney disease events by 24% in patients with type 2 diabetes and chronic kidney disease (hazard ratio 0.76

Study and participant characteristics are detailed in Table 1