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Appetite Suppression : By reducing appetite, semaglutide supports healthier eating habits and sustainable weight management

As compared with placebo, tirzepatide decreased the urine albumincreatinine ratio (UACR) at 24 weeks (ETD 25%, 95% CI 35.5 to 12.7

GLP-1RAs have also been shown to reduce liver inflammation and fibrosis

this suggests a rapid phase of GLP-1 secretion caused by direct stimulation of L-cells in the upper GI tract and a second phase potentially caused by signals from the upper gut reaching the lower small and perhaps even the large intestine [323,324]

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For the time being, the proposed treatment algorithm for patients with DM2 and NAFLD/NASH focuses on caloric restriction, especially those acquired by ingestion of fructose and alcohol, and initiation of aerobic exercise, targeting an overall body-weight reduction of 710%
