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The use of low adsorption LC column hardware has shown to be crucial for achieving good peak shape and high sensitivity for several metal-sensitive GLP-1 RA APIs, related impurities and excipients enabling the development of sensitive methods for impurity profiling with good recovery

Patients with a history of pancreatitis should be monitored closely, and alternative therapies may be considered

doi: 10.3389/fendo.2021.721135 Received 06 June 2021 Accepted 05 August 2021 Published 23 August 2021 Volume 12 - 2021 Edited by Kazunori Sango, Tokyo Metropolitan Institute of Medical Science, Japan Reviewed by Mohammad Qaddoumi, Kuwait University, Kuwait

Nevertheless, collectively these findings provide further support for a pleiotropic impact of GLP-1 on the mesolimbic circuitry and reward behavior

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