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Can GLP-1 receptor agonists be delivered through the skin at all
In the next step, we replaced the GLP-1 specific residues Val 27 , lys 28 , Gly 29 , Arg 30, and Gly 31 of I-M-150845 with the C-terminal oxyntomodulin residues Met 27 , Asn 28 , Thr 29 , Lys 30 , Arg 31 , Asn 32 , Arg 33 , Asn 34 , Asn 35 , Ile 36 , and Ala 37 to generate a new incretin agonist I-M-150846
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The decrease in ATP production could decrease hepatic gluconeogenesis (49)
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