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Alogliptin, a benzonitrile, binds noncovalently to the catalytic site of DPP4
Given the effects of GLP-1 receptor agonists on body weight and fat, the question arises of whether a reduction in kidney-specific fat depots could contribute to the kidney-protective effects of GLP-1 receptor agonist treatment
Thomas, Tirzepatide as monotherapy improved markers of beta-cell function and insulin sensitivity in type 2 diabetes (SURPASS-1)
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Regulatory bodies are increasingly approving GLP-1 therapies for obesity-specific indications
IPRA and PIO significantly improved hepatocellular hypertrophy, micro-vesicular steatosis, lobular inflammation and mild fibrosis in a dose-dependent manner, with the activities of PIO being weaker compared to those of IPRA
