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Bottom line: Feeling cold is a frequent, albeit unofficial, experience for those losing weight on GLP-1s, primarily due to the loss of fat insulation and reduced energy intake

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Injectable formulations show slightly higher nausea rates in early weeks, while oral forms may distribute side effects differently across the GI tract over longer timeframes

Neurochem 94 , 11241130 (2005)

The kidneys and liver metabolise the fatty acids, producing ketone bodies as common metabolites [56]