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It remains under clinical investigation, with Phase 3 trials ongoing at the time of writing
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Mortality and cardiovascular events in diabetes mellitus patients at dialysis initiation treated with glucagon-like peptide-1 receptor agonists

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GIP signaling further upregulates the expression of the POMC gene in these neurons and amplifies their intracellular cAMP/protein kinase A (PKA) signaling pathway, thereby enhancing the production of satiety signals
