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Description
In clinical trials including MAESTRO-NASH, Resmetirom reduced hepatic fat content (as measured by MRI-PDFF), lowered liver enzyme values, improved noninvasive markers of liver fibrogenesis, and decreased liver stiffness [125,126]
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Genetic variation in GLP-1 receptor (GLP1R), glucose-dependent insulinotropic peptide receptor (GIPR), and glucagon receptor (GCG-R) pathways also influence tolerability and response trajectory
