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Thus, the tissue content of GLP-1 is increased in islets from diabetic rodents (106, 110), and when cultured, islets obtained from human donors with T2DM or from diabetic rodents release more GLP-1 ex vivo than non-diabetic islets (98, 109, 113)

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Pharmacologic Approaches to Glycemic Treatment: Standards of Care in Diabetes-2024

Activation there reduces food intake, and it is this central action, as much as any peripheral effect, that drives the weight loss seen with GLP-1 drugs