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Our study also indicates that liver-targeted TR agonists could be tested for the treatment of type 2 diabetes in the future

Indeed, reducing blood glucose level and insulin treatment did not improve neurological dysfunction

In contrast, pathways typically linked to cellular protection, including MYC targets V1, protein secretion, DNA repair, oxidative phosphorylation, the unfolded protein response, MTORC1 signaling, and adipogenesis, were markedly downregulated (Figure 4B and Supplemental Figure 6A)

This includes high levels of expression in the neostriatum, olfactory tubercle, substantia nigra, ventral tegmental area, and the nucleus accumbens (Meador-Woodruff et al., 1989)

It mimics incretin hormones to lower blood sugar levels by enhancing insulin secretion, reducing glucagon secretion, and slowing gastric emptying