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We don't have good data on: *What outcomes look like at various sub-therapeutic doses *Which patients might benefit from lower, more frequent dosing versus higher, less frequent *How hormonal changes (hello, perimenopause) affect optimal dosing *Long-term effects of maintenance microdosing after weight loss goals are met The doctor quoted in the article is right that standard doses exist because they've been proven effective

Genetic differences in peptide pathways, dosing limits, and individual metabolism explain weight loss plateaus

The authors explicitly suggest reframing switching as part of long-term optimization rather than discontinuation

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This enzyme converts incretins,...

Compared with other second- or third-line glucose-lowering medications, the GLP-1RAs demonstrated a lower rate of adverse CVEs, including heart failure (HR 0.88