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These comorbidities are interlinked via shared immunopathogenic mechanisms, notably chronic low-grade inflammation driven by Th1/Th17 cytokines such as TNF, IL-6, and IL-17

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It details preclinical and clinical evidence linking GLP-1 receptor activation to cardiovascular, renal, hepatic, neural, and joint anti-inflammatory effects while outlining uncertainties and future research needs.

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Human clinical studies report measurable reductions in HbA1c levels, body-weightrelated endpoints, and improved insulin sensitivity markers compared to placebo-controlled groups

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