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Interestingly, GLP-1 signaling in the hippocampus has been described to play a direct and crucial role in regulating learning and memory, independent of motor, stress, or nociceptive impacts
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On one hand, it specifically activates the TLR2/NF-B signaling pathway [89], upregulates the expression of tight junction proteins, thereby effectively reducing intestinal permeability [25, 90, 91]
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Annual kidney function screening (eGFR) is prudent, as GLP-1 medications should be used cautiously when eGFR falls below 15
MI and its consequent tissue damage leading to heart failure are mainly responsible for the fatality in patients with T2DM
