surmount-2 tirzepatide type 2 diabetes weight loss results 2023 2024 Was Associated with Improved Health-Related Quality of Life in Adults with Obesity or Overweight and Diabetes: from the Phase 3 Trial | Therapy FDA approval for Zepbound (tirzepatide)
Description
Incorporating strength training protocols 2-3 times weekly preserves muscle and improves transformation quality
Weight loss in month one typically ranges from 3 to 8 pounds for men
Exercise does not drive weight loss directly (the caloric deficit from tirzepatide does the heavy lifting), but resistance training preserves lean mass, increases resting metabolic rate, and prevents the metabolic slowdown that causes plateaus
The 25 to 30 day washout is the minimum for safe transition, and extending it slightly for those on higher tirzepatide doses is prudent risk management
Accessed Oct 1, 2025
Pharmacy benefit managers (PBMs), like CVS Caremark, are constantly evaluating drugs based on their clinical effectiveness, pricing, and rebates
