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In their respective obesity programmes the triple agonist reported larger mean reductions: retatrutide reached about 24.2% at 48 weeks in Phase 2 (NEJM 2023) and 28.3% at 80 weeks in Phase 3 TRIUMPH-1, while tirzepatide reported about 20.9% at 72 weeks in SURMOUNT-1

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As the first GLP-1 medication specifically approved for weight loss, it offers substantial outcomes, with clinical trials demonstrating an average body weight reduction of 14.9%