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Tirzepatide for MASH SYNERGY-NASH trial

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This sample size provides at least 80% power for the comparison of tirzepatide versus placebo for the change in energy intake during ad libitum test meals (primary outcome) based on a two-sample t -test at an alpha level of 0.05, given an expected treatment difference of 212 kcal and an assumed common standard deviation of 289 kcal for the change in energy intake from baseline

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Sleep disruption A smaller but notable percentage of users experience insomnia on tirzepatide

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Semaglutide Acts through the GLP-1 receptor pathway to influence appetite, fullness, digestion, and blood sugar

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May your treatment choices stay informed, your weight loss stay consistent, and your health outcomes stay exactly where you want them.

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Tirzepatide fatigue can present as a general sense of tiredness, weakness, sluggishness, or lack of energy

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