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A 2022 trial showed patients regained two-thirds of their weight loss within one year of stopping semaglutide Other Key Considerations Pre-op guidance: Most patients should continue taking their glucagon-like peptide-1 (GLP-1) receptor agonists before elective surgery

In a controlled crossover trial, Shang et al

For example, some people taking GLP-1 medications have reported digestive tract side effects such as nausea, vomiting, and diarrhea

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Clinical studies have shown that semaglutide, when combined with healthy lifestyle changes such as diet and exercise, can lead to significant and sustained weight loss