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Potential risks include: Low blood sugar, especially if you also take other diabetes medications Gallbladder issues Mild to severe allergic reactions, including anaphylaxis in rare cases Possible muscle loss, if you lose weight too quickly (which is why balanced nutrition and movement matter) If youre pregnant or nursing, you should not take GLP-1s

Prevalence of obesity and severe obesity among adults: United States, 2017-2018

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Clinical psychologist Jade Gooding, CEO of the Australia & New Zealand Academy for Eating Disorders agrees that GLP-1s can mask and reinforce underlying eating disorder behaviours

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Cardiac Electrophysiology In a randomized, placebo-controlled crossover study, 79 healthy subjects were administered a single oral dose of sitagliptin 100 mg, sitagliptin 800 mg (8 times the recommended dose), and placebo