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Class B GPCRs typically bind their peptide ligands through a mechanism known as the two-domain model, in which ECD binds to the C-terminal helix of GLP-1, and the transmembrane domain (TMD) binds to the N-terminal region of GLP-1 (3, 4, 5)

Storage Instructions Important Notes How This Works GLP-3 aka Retatrutide is often described as a triple-pathway metabolic peptide because it combines three receptor targets into a single coordinated mechanism