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Ford TC, Downey LA, Simpson T, McPhee G, Oliver C, Stough C

This study, together with a companion manuscript, shows that in mice, weight loss as a result of GIP receptor antagonism requires and potentiates functional GLP-1 receptor signalling in the brain, explaining how both GIP receptor agonists and antagonists trigger weight loss through different mechanisms.

B vitamins underpin the energy production pathways these processes run on

RAF Scores: HCC 18 0.302 HCC 19 0.105 MEAT Criteria Element Example Monitor Blood glucose levels, A1C, weight, foot exam, eye exam Evaluate Review of A1C results, renal function, or symptoms Assess Type 2 DM uncontrolled with A1C 8.9%, worsening neuropathy Treat Prescribed Metformin, adjusted insulin dose, dietary counseling TAMPER Criteria Component Example T Treatment Oral hypoglycemics, insulin therapy A Assessment A1C 8.9%, not at goal M Monitor Follow-up labs, blood sugar log P Plan Recheck A1C in 3 months