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NAD+ plays crucial roles in maintaining genomic stability through its function as a substrate for poly(ADP-ribose) polymerases (PARPs), a family of enzymes that detect and respond to DNA damage by catalyzing the synthesis of poly(ADP-ribose) polymers from NAD+

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Even low levels of intakesuch as one to two drinks per weekcan measurably increase oxidative stress and alter nutrient metabolism over time, particularly in individuals with existing metabolic, inflammatory, or stress-related vulnerabilities

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StatPearls Publishing, Treasure Island Antonelli A, Ferrari SM, Corrado A, Di Domenicantonio A, Fallahi P (2015) Autoimmune thyroid disorders