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Some evidence suggests that in AD, dysregulation of tight junction proteins, increased matrix metalloproteinase signaling, and degeneration and loss of pericytes may all contribute to BBB leakage, leading to the accumulation of numerous blood-derived neurotoxic proteins in the brain, causing neuroinflammation and oxidative stress

Since regulation of KCC2 expression is also mediated by BDNF (Rivera et al

[DOI] [PMC free article] [PubMed] [Google Scholar] 256.Schneeberger M, Everard A, Gmez-Valads AG, Matamoros S, Ramrez S, Delzenne NM, et al

Incidence and characteristics of kidney stones in patients on ketogenic diet: A systematic review and Meta-Analysis

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