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Figure 2 Compartmentalization of glutathione biosynthesis is unique to plants (Noctor et al., Plant GlutamateCysteine Ligase: Structure, Function, and Regulation Glutamatecysteine ligase catalyzes the ATP-dependent formation of a peptide bond between glutamate and cysteine in the first reaction of glutathione synthesis
Aksoy YA, Yang B, Chen W, et al
doi: 10.1371/journal.pgen.1006907 179
Nature 460 , 392395 (2009)
The formation of TLS was suppressed in the kidneys of sulfasalazine-treated mice on day 21, although still observed (Figure 5, A and B, Supplemental Figure 12)
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