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NNMT is an enzyme that grabs nicotinamide and methylates it, turning it into a waste product called 1-MNA that gets cleared from the body

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The peptides development was ultimately discontinued in 2007 after a 24-week Phase III trial failed to demonstrate statistically significant weight loss compared to placebo, though research into its regenerative properties has continued

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1 Aged Muscle Stem Cell Rejuvenation Neelakantan et al., Biochemical Pharmacology (2019) In a follow-up study, the authors tested whether NNMT inhibition could reverse the age-related decline in muscle stem cell (satellite cell) function