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Concurrently, some NRTIs inhibit mitochondrial DNA polymerase , leading to mtDNA depletion and the accumulation of deletions and point mutations (2123)
further improved this approach by directly conjugating the azo group to rhodamine, which when cleaved under hypoxia, restore their fluorescence 121
therefore you can see that a vicious cycle exists
The Journal of clinical endocrinology and metabolism , 96 (3), E463E472
promoted the permeability of the loaded drug to the BBB[128]
