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Like at AMYRs, these features require the expansion of extracellular TM bundle of CTR through outward movements of TM1, ECL1/TM3, TM4/ECL2 and a small shift in the positioning of the mid-region of the peptide at the start of the N-terminal helix, relative to rAmy when bound to the CTR in the bypass conformation (Fig
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They use another protein, FOXO4, to keep p53 stuck in the nucleus so it cannot trigger cell death
Kirsner JB
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Serum methylmalonic acid and holotranscobalamin-II as markers for vitamin B 12 deficiency in end-stage renal disease patients Ann Clin Lab Sci 2013;43:243-9
