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Semaglutide primarily targets GLP-1 alone, while Retatrutide extends beyond GLP-1/GIP into glucagon receptor agonism

Disturbances in calciumphosphate metabolism, acidbase balance, and vitamin D synthesis are common in chronic kidney disease and have been linked to altered synaptic function, excitotoxicity, and reduced dopaminergic neuronal resilience [33]
doi: 10.1016/j.pharmthera.2013.08.003 128 KamelF.UmbachD

J.Huerta-CervantesM.Riveros-RosasH.Manzo-AvalosS.Aguilera-MndezA.HuertaM.et al (2024)

Absorbance was measured at 490nm at a GloMax 96 well plate reader (Promega)