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Hybertson BM, Gao B (2014) Role of the Nrf2 signaling system in health and disease

In addition, HT has been seen to lead to the inhibition of signaling pathways such as Akt, STAT3, and EGFR in pancreatic, prostate, and thyroid cancer cell lines [50,51]

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Because of these, it is challenging to determine a single stress-induced pathway that protects plants from all heavy metals