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Repletion of vitamin B12 may improve response in patients resistant to antidepressants (10) , and in older adults with major depression, long-term supplementation with a combination of B12, B6, and folic acid enhanced antidepressant treatment efficacy (40)

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Using a sterile syringe, the recommended volume of bacteriostatic water is drawn up, ensuring accuracy and minimizing air bubbles

These advantages prove the value of being extremely attentive to the selection of the bacteriostatic diluent and reconstitution solution

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For acute pain crises, cortisone may be more practical