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It has been suggested that LT-BM damage brought on by chemotherapy contributes to the pathophysiology of BM suppression by inducing HSC senescence as a result of increased ROS generation

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10.1007/s00394-009-0003-4 97 MaG.PanB.ChenY.GuoC.ZhaoM.ZhengL.et al (2017)

Acetic acid, the most abundant SCFA in the colon with more than half of the total SCFA detected in feces, can be generated by carbohydrate fermentation, or synthesized from hydrogen and carbon dioxide or formic acid through the Wood-Ljungdahl pathway (Miller and Wolin, 1996