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While topical application of pure L-Carnosine at 1% concentration fails to produce measurable accumulation in the aqueous humor, N-acetyl-L-Carnosine at similar concentrations achieves therapeutic levels capable of exerting antioxidant, anti-glycation, and protein-protective effects

The links to cancer-related pathways cannot be ignored, and the absence of human safety data is glaring

it heavily targets the gastrointestinal tract due to the high concentration of ACE2 receptors found on the surface of intestinal enterocytes

It is a widely used and effective chemotherapy protocol for advanced colorectal and other gastrointestinal cancers

Notes: Comfort is the key to consistency

The literature review was conducted independently by two investigators (A.G., P.O.) to reduce bias and ensure accurate data collection