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Taken together, our work has detailed that FUS/TLS interacts with SMN and U1-snRNP (Fig

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[DOI] [PMC free article] [PubMed] [Google Scholar] 151.Kiland J.A., Voss A.M., McLellan G.J

After degenerative changes occur in the disc, the annulus fibrosus can break, leading to the protrusion or bulging of the nucleus pulposus, either independently or in conjunction with the annulus fibrosus and the cartilaginous plate

Further, several molecules, including tumor necrosis factor alpha (TNF), leptin, -amyloid, delta-sleep inducing peptide (DSIP), and prostaglandin D2 (PGD2) display changes of rhythmic entry into murine CNS ( Bmal1 deficient mice display hyperpermeability and downregulation of platelet-derived growth factor receptor (PDGFR), suggesting a significant role for Bmal1 in pericyte regulation for blood-brain barrier maintenance (Nakazato et al., 2017)