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PMOS Part 2: Functional Medicine Treatment The conventional treatment of PMOS Polyendocrine Metabolic Ovarian Syndrome (formerly known as PCOS) is often focused on reducing the androgens and treating the metabolic dysfunction (hyperinsulinemia and insulin resistance) which are hallmark features of the condition

Regarding altered ER activity, undermethylation of the ERB promoter inhibits estrogen-induced PR expression, thereby reducing progesterone sensitivity (27)

They solve different problems

This is expected given their shared GLP-1 receptor agonism, which slows gastric emptying and alters gut motility

Some patients notice changes sooner than others, while some goals may require more time and follow-up

Preparing oral tirzepatide Compounded sublingual drops typically come ready to use
