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Am J Hum Genet

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Tissue-level deficiency of cobalamin is associated with an increase in the urinary and serum concentrations of an organic acid called methylmalonic acid, which is an alternative product of a cobalamin dependent pathway within the mitochondria

Caspases 3 and 7, key mediators of the mitochondrial apoptotic pathway, were significantly activated by (M+D)/2 after 24 hours in IMR-5/75 -Dox and IMR-32, but not in Be(2)-C and SH-SY5Y/MYCN cells

Over-the-counter numbing creams or gels can be applied to the injection site before the injection to help reduce pain