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FIGURE 1 The application of antioxidants in polycystic ovary syndrome Based on a large number of studies confirming that PCOS patients do exhibit varying degrees of OS, antioxidant therapy may become an important direction for the treatment of PCOS (74) (Table 1)

, 2016) in a glutathionylation reaction that is reversed by GRX1

While NO is essential at physiological concentration, its overproduction has been associated with neurotoxicity, apoptosis, and extensive tissue damage across multiple organs [46, 47]

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however, ATP is not usually considered a limiting factor in GSH production except in pathological conditions [10]