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Epidemiological studies indicate that VaD accounts for 1520% of dementia cases in Europe and the United States, and up to 30% in developing countries, placing a significant medical and economic burden on societies and families (Wolters and Ikram, 2019)

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Immobilization stress has also been reported to induce 2-3 fold higher rise of plasma cortisol level

4.3.4 Chemotherapeutic agents Chemotherapeutic agents such as anthracyclines and kinase inhibitors are known for their adverse effects