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Next steps in clinical translation First-in-human safety trials (phase I) are essential: to assess dose tolerability, pharmacokinetics, biodistribution, peptide half-life, clearance, immunogenicity

Liver Digest Medium: HBSS, calcium, magnesium, no phenol red, 25 mM HEPES, penicillin-streptomycin (10,000 U/mL), 3.6 mg Trypsin Inhibitor (Sigma, St

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This spans successive time points during anagen (P10P16) in both wild-type and mutant mice (Supplementary Fig

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Because tissue repair isnt just turning inflammation off. For tendons and ligaments, the remodeling process can require repeated loading cycles, adequate protein intake, and time for collagen reorganization