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During early tumorigenesis, autophagy preserves genomic integrity and homeostasis by removing damaged organelles and limiting oxidative stress

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Under normal conditions, there is a well-regulated equilibrium in the GI mucosa between inflammatory cytokines (such as TNF-, IL-1, IL-6, IL-8, IL-17, and IL-23) and anti-inflammatory cytokines (like IL-5, IL-10, IL-11, and TGF-) (75)

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